The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

Lauren L Campbell Marotta, Vanessa Almendro, Andriy Marusyk, +25

Journal of Clinical Investigation

Breast OncologyImmunologyCell ProliferationCancer BiologyTumor Biology +19

Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors

Juliann Chmielecki, Aimeé M. Crago, Mara Rosenberg, +8

Nature Genetics

Solitary Fibrous TumorsEngineeringRecurrent Nab2-stat6 FusionTumor HeterogeneityMedicine +10

A single-cell landscape of high-grade serous ovarian cancer

Benjamin Izar, Itay Tirosh, Elizabeth H. Stover, +31

Nature Medicine

Tumor HeterogeneityMedicineGynecologySingle-cell LandscapeOncology +3

IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment

Tatiana A. Karakasheva, Eric W. Lin, Qiaosi Tang, +19

Cancer Research

The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors

Erik A. Nelson, Sarah R. Walker, Ellen Weisberg, +10

Blood

Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of <i>ERBB2</i>

Heidi Greulich, Bethany Kaplan, Philipp Mertins, +25

Proceedings of the National Academy of Sciences

Systems BiologySignal TransductionEngineeringTransformation AssaysSignaling Pathway +12

Fold Change of Nuclear NF-κB Determines TNF-Induced Transcription in Single Cells

Robin Lee, Sarah R. Walker, Kate Savery, +2

Molecular Cell

Transcriptional RegulationFold ChangeCell RegulationMedicineImmunology +9

Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3

Erik A. Nelson, Sarah R. Walker, Alicia Kepich, +6

Blood

STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF-κB to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes

Michael Xiang, Nicolai J. Birkbak, Vida Vafaizadeh, +9

Science Signaling

Reciprocal Effects of STAT5 and STAT3 in Breast Cancer

Sarah R. Walker, Erik A. Nelson, Lihua Zou, +4

Molecular Cancer Research

Tumor BiologySystems BiologyBreast OncologyMedicineStat3 Activation +11