Renske Wiegertjes

A roadmap to target interleukin-6 in osteoarthritis

Renske Wiegertjes, Fons A. J. van de Loo, E.N. Blaney Davidson · Lara D. Veeken · 2020 · 154 citations · Full text

Inflammation, Rheumatology, Cytokine +14

TGF-β dampens IL-6 signaling in articular chondrocytes by decreasing IL-6 receptor expression

Renske Wiegertjes, A. van Caam, H. van Beuningen et al. · Osteoarthritis and Cartilage · 2019 · 60 citations

Increased IL-6 receptor expression and signaling in ageing cartilage can be explained by loss of TGF-β-mediated IL-6 receptor suppression

Renske Wiegertjes, Nathalie G. M. Thielen, A. van Caam et al. · Osteoarthritis and Cartilage · 2021 · 24 citations · Full text

Osteoarthritis-Related Inflammation Blocks TGF-β’s Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region

Nathalie G. M. Thielen, M. Neefjes, Renske Wiegertjes et al. · International Journal of Molecular Sciences · 2021 · 23 citations · Full text

Immunology, Orthopaedic Surgery, Inflammatory Arthritis +20

Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1

Asha M. Rudjord-Levann, Zilu Ye, Lise Hafkenscheid et al. · iScience · 2023 · 20 citations · Full text