4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

Marcello Trevisani, Jan Siemens, Serena Materazzi, +12

Proceedings of the National Academy of Sciences

Pain MedicineImmunologyNeuropathic PainMolecular PainInflammation +20

Protease‐activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

Andrew Grant, Graeme S. Cottrell, Silvia Amadesi, +15

The Journal of Physiology

Cigarette smoke–induced neurogenic inflammation is mediated by α,β-unsaturated aldehydes and the TRPA1 receptor in rodents

Eunice Andrè, Barbara Campi, Serena Materazzi, +12

Journal of Clinical Investigation

Inflammatory Lung DiseaseLung InflammationImmunologyTrpa1-deficient Miceβ-Unsaturated Aldehydes +17

The TGR5 receptor mediates bile acid–induced itch and analgesia

Farzad Alemi, Edwin Kwon, Daniel P. Poole, +15

Journal of Clinical Investigation

Pain MedicineNeuropathic PainMolecular PainMolecular PharmacologyCell Signaling +18

Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation

Romina Nassini, Maarten Gees, Selena Harrison, +12

Pain

Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice

Francesco De Logu, Romina Nassini, Serena Materazzi, +12

Nature Communications

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Dane D. Jensen, TinaMarie Lieu, Michelle L. Halls, +23

Science Translational Medicine

Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation

Romina Nassini, Pamela Pedretti, Nadia Moretto, +13

PLoS ONE

TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism

Serena Materazzi, Camilla Fusi, Silvia Benemei, +7

Pflügers Archiv - European Journal of Physiology

Molecular PharmacologyMolecular PhysiologyG Protein-coupled ReceptorMedicineMolecular Pain +8

The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

TinaMarie Lieu, Gihan Jayaweera, Peishen Zhao, +15

Gastroenterology

Trpa1 ChannelMolecular PhysiologySignal TransductionAllergyBiliary Tract +8