Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome

Giovanni Barbara, Bingxian Wang, Vincenzo Stanghellini, +10

Gastroenterology

Pain SyndromeVisceral-nociceptive Sensory NeuronsHealth SciencesFunctional Gastrointestinal DisorderNeuroanatomy +11

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

Marcello Trevisani, Jan Siemens, Serena Materazzi, +12

Proceedings of the National Academy of Sciences

Pain MedicineImmunologyNeuropathic PainMolecular PainInflammation +20

Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1

Marcello Trevisani, D Smart, Martin J. Gunthorpe, +14

Nature Neuroscience

Health SciencesPain MedicineMedicinePhysiologyNeuropathic Pain +8

Cigarette smoke–induced neurogenic inflammation is mediated by α,β-unsaturated aldehydes and the TRPA1 receptor in rodents

Eunice Andrè, Barbara Campi, Serena Materazzi, +12

Journal of Clinical Investigation

Inflammatory Lung DiseaseLung InflammationImmunologyTrpa1-deficient Miceβ-Unsaturated Aldehydes +17

Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels

Mario van der Stelt, Marcello Trevisani, Vittorio Vellani, +6

The EMBO Journal

Ca2+ InfluxMolecular PhysiologySignal TransductionBiochemistryMedicine +9

Hydrogen Sulfide Is a Novel Prosecretory Neuromodulator in the Guinea-Pig and Human Colon

Rudolf Schicho, Dagmar Krueger, Florian Zeller, +7

Gastroenterology

NeurophysiologyMedicinePhysiologyNovel Prosecretory NeuromodulatorNeurotransmitter +12

Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

Serena Materazzi, Romina Nassini, Eunice Andrè, +6

Proceedings of the National Academy of Sciences

Neurogenic responses mediated by vanilloid receptor‐1 (TRPV1) are blocked by the high affinity antagonist, iodo‐resiniferatoxin

Michela Rigoni, Marcello Trevisani, David Gazzieri, +8

British Journal of Pharmacology

Ethanol Causes Inflammation in the Airways by a Neurogenic and TRPV1-Dependent Mechanism

Marcello Trevisani, David Gazzieri, Francesca Benvenuti, +9

Journal of Pharmacology and Experimental Therapeutics

Development of the First Ultra-Potent “Capsaicinoid” Agonist at Transient Receptor Potential Vanilloid Type 1 (TRPV1) Channels and Its Therapeutic Potential

Giovanni Appendino, Luciano De Petrocellis, Marcello Trevisani, +10

Journal of Pharmacology and Experimental Therapeutics