The menthol receptor TRPM8 is the principal detector of environmental cold

Diana M. Bautista, Jan Siemens, Joshua Glazer, +5

Nature

Environmental ColdSignal TransductionAllergyPhysiologyMedicine +3

TRPA1 mediates formalin-induced pain

Colleen R. McNamara, Josh Mandel-Brehm, Diana M. Bautista, +8

Proceedings of the National Academy of Sciences

Pain MedicineMolecular PainNeurotransmissionCellular PhysiologyPain Syndrome +17

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

Marcello Trevisani, Jan Siemens, Serena Materazzi, +12

Proceedings of the National Academy of Sciences

Pain MedicineImmunologyNeuropathic PainMolecular PainInflammation +20

Cadherin 23 is a component of the tip link in hair-cell stereocilia

Jan Siemens, Concepción Lillo, Rachel A. Dumont, +4

Nature

Developmental BiologyCell InteractionMolecular BiologyMorphogenesisTip Link +6

The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia

Kun Song, Hong Wang, Gretel B. Kamm, +5

Science

Trp ChannelsHomeostatic MechanismThermal TherapyPhysiological RegulationCellular Physiology +16

Spider toxins activate the capsaicin receptor to produce inflammatory pain

Jan Siemens, Sharleen Zhou, Rebecca A. Piskorowski, +5

Nature

InflammationAnti-inflammatoryToxinologyMedicineImmunology +4

Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells

Christian Söllner, Gerd-Jörg Rauch, Jan Siemens, +4

Nature

Skin DevelopmentDevelopmental BiologyMolecular PhysiologyDevelopmental GeneticsGenetics +6

A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

Christopher J. Bohlen, Avi Priel, Sharleen Zhou, +3

Cell

Bivalent Tarantula ToxinSignal TransductionOuter Pore DomainBiochemistryToxinology +7

The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions

Jan Siemens, Piotr Kaźmierczak, Anna Reynolds, +3

Proceedings of the National Academy of Sciences

Type 1Usher Syndrome ProteinsSignal TransductionCause DeafnessSignaling Pathway +13

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Jérôme Wahis, Angel Baudon, Ferdinand Althammer, +34

Nature Neuroscience

Affective StatesNeurophysiologyNeuroanatomyPhysiologyAffective Neuroscience +9