SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

Naoko Irie, Leehee Weinberger, Walfred W. C. Tang, +6

Cell

Germ Cell BiologyCell LineageHuman CellDevelopmental BiologyCritical Specifier +10

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

Chen Zhao, Naoko Irie, Yasunari Takada, +5

Cell Metabolism

Signal TransductionOsteoporosisBone HomeostasisMedicineCell Biology +1

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

Walfred W. C. Tang, Sabine Dietmann, Naoko Irie, +6

Cell

Principles of early human development and germ cell program from conserved model systems

Toshihiro Kobayashi, Haixin Zhang, Walfred W. C. Tang, +10

Nature

Germ Cell BiologyBiologyHuman CellDevelopmental BiologyGerm Cell +12

Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos

Vasileios I. Floros, Angela Pyle, Sabine Dietmann, +15

Nature Cell Biology

BiologyDevelopmental BiologyDnaMitochondrial FunctionMedicine +10

Bidirectional Signaling through EphrinA2-EphA2 Enhances Osteoclastogenesis and Suppresses Osteoblastogenesis

Naoko Irie, Yasunari Takada, Yoshihiko Watanabe, +6

Journal of Biological Chemistry

Ephrina2 ReverseSclerostinDevelopmental BiologySignal TransductionBone Morphogenic Protein +10

Germline competency of human embryonic stem cells depends on eomesodermin

Di Chen, Wanlu Liu, Anastasia Lukianchikov, +9

Biology of Reproduction

GeneticsEmbryologyTranscriptional RegulationPrimitive Streak GenesGerm Cell Development +19

Germ cell specification and pluripotency in mammals: a perspective from early embryogenesis

Naoko Irie, Walfred W. C. Tang, M. Azim Surani

Reproductive Medicine and Biology

Sequential enhancer state remodelling defines human germline competence and specification

Walfred W. C. Tang, Aracely Castillo-Venzor, Wolfram H. Gruhn, +6

Nature Cell Biology

Germ Cell BiologyDevelopmental BiologySequential Enhancer StateGerm CellGenetics +5

A PAX5–OCT4–PRDM1 developmental switch specifies human primordial germ cells

Fang Fang, Benjamin Angulo, Ninuo Xia, +11

Nature Cell Biology

Germ Cell BiologyDevelopmental BiologyGerm CellPrimordial Germ Cell DevelopmentPrimordial Germ Cells +8