Angela Pyle

Use of Whole-Exome Sequencing to Determine the Genetic Basis of Multiple Mitochondrial Respiratory Chain Complex Deficiencies

Robert W. Taylor, Angela Pyle, Helen Griffin et al. · JAMA · 2014 · 361 citations · Full text

Clinical Expression of Leber Hereditary Optic Neuropathy Is Affected by the Mitochondrial DNA–Haplogroup Background

Gavin Hudson, Valério Carelli, Liesbeth Spruijt et al. · The American Journal of Human Genetics · 2007 · 356 citations · Full text

Neurodegenerative Diseases, Clinical Expression, Ophthalmology +10

Efficient mitochondrial biogenesis drives incomplete penetrance in Leber’s hereditary optic neuropathy

Carla Giordano, Luisa Iommarini, Luca Giordano et al. · Brain · 2013 · 281 citations · Full text

Biology, Neurodegenerative Diseases, Molecular Neuroscience +14

Reduced mitochondrial DNA copy number is a biomarker of Parkinson's disease

Angela Pyle, Haidyan Anugrha, Marzena Kurzawa‐Akanbi et al. · Neurobiology of Aging · 2015 · 252 citations · Full text

Mitochondrial Dna Mtdna, Genetics, Molecular Biology +17

Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos

Vasileios I. Floros, Angela Pyle, Sabine Dietmann et al. · Nature Cell Biology · 2018 · 243 citations · Full text

Biology, Developmental Biology, Dna +12