Derivation of novel human ground state naive pluripotent stem cells

Ohad Gafni, Leehee Weinberger, Abed AlFatah Mansour, +24

Nature

Tissue EngineeringInduced Pluripotent Stem CellDevelopmental BiologyMedicineInduced Pluripotent Stem Cells +7

SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

Naoko Irie, Leehee Weinberger, Walfred W. C. Tang, +6

Cell

Germ Cell BiologyCell LineageHuman CellDevelopmental BiologyCritical Specifier +10

Deterministic direct reprogramming of somatic cells to pluripotency

Yoach Rais, Asaf Zviran, Shay Geula, +23

Nature

Induced Pluripotent Stem CellDevelopmental BiologyCell ReprogrammingGenetic EngineeringDeterministic Direct Reprogramming +3

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

Abed AlFatah Mansour, Ohad Gafni, Leehee Weinberger, +16

Nature

ChromatinChromatin RemodelingEpigenetic ChangeGeneticsMolecular Epigenetics +9

Principles of signaling pathway modulation for enhancing human naive pluripotency induction

Jonathan Bayerl, Muneef Ayyash, Tom Shani, +26

Cell stem cell

Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors

Itay Maza, Inbal Caspi, Asaf Zviran, +14

Nature Biotechnology

Induced Pluripotent Stem CellTransient AcquisitionDevelopmental BiologyHealth SciencesSomatic Cell Genetics +9

Expression Noise and Acetylation Profiles Distinguish HDAC Functions

Leehee Weinberger, Yoav Voichek, Itay Tirosh, +3

Molecular Cell

EngineeringMolecular BiologyNoiseBiomedical AnalysisSignal Processing +4

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules

Asaf Zviran, Nofar Mor, Yoach Rais, +33

Cell stem cell

ChromatinTranscriptional RegulationSystems BiologyChromatin RemodelingSomatic Cell Genetics +12

Transcriptional programs that control expression of the autoimmune regulator gene Aire

Yonatan Herzig, Shir Nevo, Chamutal Bornstein, +18

Nature Immunology

Transcriptional RegulationSystems BiologyAutoimmune DiseaseImmunologyTranscriptional Programs +7

HER2 and HLA-A*02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicity

David Bassan, Leehee Weinberger, Jason Yi, +14

Journal for ImmunoTherapy of Cancer