Rosemary Burke

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

Georgios Vlachogiannis, Somaieh Hedayat, Alexandra Vatsiou et al. · Science · 2018 · 1.9K citations · Full text

Exploiting evolutionary steering to induce collateral drug sensitivity in cancer

Ahmet Acar, Daniel Nichol, Javier Fernández-Mateos et al. · Nature Communications · 2020 · 124 citations · Full text

MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma

Andrea Lampis, Pietro Carotenuto, Georgios Vlachogiannis et al. · Gastroenterology · 2017 · 111 citations · Full text

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

Aurélie Mallinger, Kai Schiemann, Christian Rink et al. · Journal of Medicinal Chemistry · 2016 · 110 citations · Full text

Vivo Metabolic Clearance, Medicinal Chemistry, Signaling Pathway +18

8-Substituted Pyrido[3,4-<i>d</i>]pyrimidin-4(3<i>H</i>)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Vassilios Bavetsias, Rachel M. Lanigan, G.F. Ruda et al. · Journal of Medicinal Chemistry · 2016 · 97 citations · Full text

Combinatorial Chemistry, Pharmaceutical Science, Drug Target +19