Jitka Poljaková

The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, through Metabolism to 13-Hydroxyellipticine and Ellipticine<b><i>N</i></b>2-Oxide

Marie Stiborová, Jan Sejbal, Lucie Bořek-Dohalská et al. · Cancer Research · 2004 · 133 citations

Medicine, Biochemistry, Pharmacology +11

Ellipticine cytotoxicity to cancer cell lines - a comparative study

Marie Stiborová, Jitka Poljaková, Eva Martínková et al. · Interdisciplinary Toxicology · 2011 · 81 citations · Full text

Medicine, Oncology, Pharmacology +17

The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells

Jitka Poljaková, Tomáš Eckschlager, Jan Hraběta et al. · Biochemical Pharmacology · 2009 · 65 citations · Full text

Medicine, Biochemistry, Oncology +13

Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found <i>in vivo</i> and generated from 12‐hydroxyellipticine and 13‐hydroxyellipticine

Marie Stiborová, Jitka Poljaková, Helena Ryšlavá et al. · International Journal of Cancer · 2006 · 60 citations · Full text

Medicine, Biochemistry, Pharmacology +12

DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells

Jitka Poljaková, Eva Frei, Dagmar Aimová et al. · Cancer Letters · 2007 · 42 citations

Medicine, Oncology, Pharmacology +8