Eva Frei

Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes.

Marie Stiborová, Václav Martínek, Helena Rýdlová et al. · PubMed · 2002 · 274 citations

Metabolic Activation, Pathology, Toxicological Mechanism +20

The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts☆

Marie Stiborová, Christian A. Bieler, Eva Frei · Biochemical Pharmacology · 2001 · 148 citations

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +8

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice

Volker M. Arlt, Marie Stiborová, Colin J. Henderson et al. · Carcinogenesis · 2007 · 142 citations · Full text

The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, through Metabolism to 13-Hydroxyellipticine and Ellipticine<b><i>N</i></b>2-Oxide

Marie Stiborová, Jan Sejbal, Lucie Bořek-Dohalská et al. · Cancer Research · 2004 · 133 citations

Environmental Pollutant and Potent Mutagen 3-Nitrobenzanthrone Forms DNA Adducts after Reduction by NAD(P)H:Quinone Oxidoreductase and Conjugation by Acetyltransferases and Sulfotransferases in Human Hepatic Cytosols

Volker M. Arlt, Marie Stiborová, Colin J. Henderson et al. · Cancer Research · 2005 · 121 citations