Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Georgia Hatzivassiliou, Jacob R. Haling, Huifen Chen, +18

Nature

OncologyMedicineReceptor Tyrosine KinaseCancer GeneticsRadiation Oncology +4

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling

Jacob R. Haling, Jawahar Sudhamsu, Ivana Yen, +12

Cancer Cell

Braf-mek ComplexSignal TransductionSignaling PathwayCell RegulationReceptor Tyrosine Kinase +5

Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states

Claudia Macaubas, Khoa D. Nguyen, Chetan Deshpande, +6

Clinical Immunology

InflammationRheumatologyRheumatoid DisorderAutoimmune DiseaseDisease Activity States +8

Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site

Fanny Sunden, Ariana Peck, Julia Salzman, +2

eLife

Molecular BiologyFunctional UnitsEnzymologyBioenergeticsEnzymes Enable Life +14

Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy

Jamie B. Spangler, Eleonora Trotta, Jakub Tomala, +10

The Journal of Immunology

Alternative activation in systemic juvenile idiopathic arthritis monocytes

Claudia Macaubas, Khoa D. Nguyen, Ariana Peck, +16

Clinical Immunology

InflammationRheumatologyAlternative ActivationRheumatoid DisorderAutoimmune Disease +7

Conformational heterogeneity of the calmodulin binding interface

Diwakar Shukla, Ariana Peck, Vijay S. Pande

Nature Communications

Montage electron tomography of vitrified specimens

Ariana Peck, Stephen D. Carter, Huanghao Mai, +3

Journal of Structural Biology

Computed TomographyEngineeringElectron MicroscopyMedical ImagingMicroscopy +6

Structural insights into functional properties of the oxidized form of cytochrome c oxidase

Izumi Ishigami, Raymond G. Sierra, Zhen Su, +11

Nature Communications

Tungstate as a Transition State Analog for Catalysis by Alkaline Phosphatase

Ariana Peck, Fanny Sunden, Logan D. Andrews, +2

Journal of Molecular Biology

Transition State AnalogBiochemistryIndustrial CatalysisNatural SciencesAlkaline Phosphatase +4