Concepedia

Sabine Schlyer

SS

6

Publications

287

Citations

6

H-Index

2006

Active since

Affiliations

Boehringer Ingelheim (United States)(Current)

Sabine Schlyer is an author at Boehringer Ingelheim (United States) specializing in medicinal chemistry, drug discovery, and medicine.

Top concepts

MedicinePharmacologyDrug DiscoveryMedicinal ChemistryBiochemistryPharmacotherapyNatural SciencesDrug DevelopmentPhysiologyHypertension

Publications per year

2006–2010

6

Publications

6

Predictions of CCR1 Chemokine Receptor Structure and BX 471 Antagonist Binding Followed by Experimental Validation

Nagarajan Vaidehi, Sabine Schlyer, Rene J. Trabanino et al. · Journal of Biological Chemistry · 2006 · 100 citations · Full text

Agonist activation of the G protein‐coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα<sub>13</sub> and β‐arrestin‐2

Laura Jenkins, Elisa Alvarez‐Curto, Kate Campbell et al. · British Journal of Pharmacology · 2010 · 78 citations · Full text

Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 3, aryl substituted pyrrolidines

Todd Bosanac, Eugene R. Hickey, John D. Ginn et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 44 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +13

SAR studies of non-zinc-chelating MMP-13 inhibitors: Improving selectivity and metabolic stability

Donghong A. Gao, Zhaoming Xiong, Alexander Heim‐Riether et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 30 citations · Full text

Medicinal Chemistry, Metabolic Stability, Biochemistry +10

Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats

John D. Ginn, Todd Bosanac, Rhonda Chen et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 22 citations · Full text

Hypertension, Medicinal Chemistry, Part 2 +10

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