Concepedia

Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats

John D. Ginn, Todd Bosanac, Rhonda Chen, Charles L. Cywin, Eugene R. Hickey, Mohammed A. Kashem, Steven Kerr, Stanley Kugler, Xiang Li, Anthony S. Prokopowicz,

Bioorganic & Medicinal Chemistry Letters · 2010 · 22 citations · 19 references

DOIFull text

Open access

Concepts

References

19

Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Daniel F. Veber, Stephen R. Johnson, Hung‐Yuan Cheng et al. · Journal of Medicinal Chemistry · 2002 · 8.1K citations

, , +15

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

Mutsuki Amano, Kazuyasu Chihara, Kazushi Kimura et al. · Science · 1997 · 1.1K citations

, , +17

Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction

Katsuyuki Nagatoya, Toshiki Moriyama, Noritaka Kawada et al. · Kidney International · 2002 · 217 citations

, , +9

Rho Kinase Inhibition Improves Endothelial Function in Human Subjects With Coronary Artery Disease

Anju Nohria, Matthew E. Grunert, Yoshiyuki Rikitake et al. · Circulation Research · 2006 · 172 citations · Full text

, , +17

Novel Rho Kinase Inhibitors with Anti-inflammatory and Vasodilatory Activities

Chris P. Doe, Ross Bentley, David J. Behm et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 156 citations · Full text

, , +11