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Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats

HypertensionMedicinal ChemistryPart 2Blood Pressure ReductionPhysiologyMedicineCardiovascular PharmacologyAntihypertensive TherapyPotent Rho-kinase InhibitorsPharmacotherapyPharmacologyBlood PressureDrug Discovery