Design of amidobenzimidazole STING receptor agonists with systemic activity

Joshi M. Ramanjulu, G. Scott Pesiridis, Jingsong Yang, +42

Nature

Systemic ActivityMedicineMechanism Of ActionPharmacological AgentPharmacotherapy +2

Discovery of Thieno[3,2-<i>d</i>]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3

Jeremy S. Disch, Ghotas Evindar, Cynthia H. Chiu, +15

Journal of Medicinal Chemistry

Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor

Zining Wu, Todd L. Graybill, Xin Zeng, +19

ACS Combinatorial Science

Drug TargetImmunologyMolecular BiologyCell-based SelectionSmall-molecule Ligands +18

Efficient one-pot preparation of 5-substituted-2-amino-1,3,4-oxadiazoles using resin-bound reagents

Frank T. Coppo, Karen A. Evans, Todd L. Graybill, +1

Tetrahedron Letters

Organic ChemistryPharmacologySynthesis MethodEfficient One-pot Preparation

Preparation and evaluation of peptidic aspartyl hemiacetals as reversible inhibitors of interleukin‐l β converting enzyme (ICE)

Todd L. Graybill, Roland E. Dolle, Carla T. Helaszek, +2

International journal of peptide & protein research

Pharmaceutical SciencePeptide ScaffoldImmunologyPeptide SciencePharmacotherapy +15

Synthesis and evaluation of azapeptide-derived inhibitors of serine and cysteine proteases

Todd L. Graybill, Mitchell J. Ross, Bruce R. Gauvin, +5

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesAzapeptide-derived Inhibitors +9

Pyridazinodiazepines as a High-Affinity, P₂−P₃Peptidomimetic Class of Interleukin-1β-Converting Enzyme Inhibitor

Roland E. Dolle, C. V. C. Prasad, Catherine Prouty, +10

Journal of Medicinal Chemistry

ImmunologyAltmetric Attention ScoreInterleukin-1β-converting Enzyme InhibitorPharmacotherapySystem Pharmacology +17

Aspartyl .alpha.-((1-Phenyl-3-(trifluoromethyl)- pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1.beta. Converting Enzyme Inhibitors. Significance of the P1 and P3 Amido Nitrogens for Enzyme-Peptide Inhibitor Binding

Roland E. Dolle, J. B. Singh, James M. Rinker, +6

Journal of Medicinal Chemistry

Altmetric Attention ScorePharmacotherapyAspartyl .Alpha.-Chemical BiologyPharmaceutical Chemistry +14

An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: Potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase

Karen A. Evans, Deping Chai, Todd L. Graybill, +5

Bioorganic & Medicinal Chemistry Letters

Asymmetric Solid-phase SynthesisBiochemistryAntiviral TherapyVirologyBenzothiadiazine-substituted Tetramic Acids +4

Camphor sulfonamide derivatives as novel, potent and selective CXCR3 antagonists

Yonghui Wang, Jakob Busch‐Petersen, Feng Wang, +14

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceMedicineNatural Sciences +9