In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates

Kiran Musunuru, Alexandra C. Chadwick, Taiji Mizoguchi, +39

Nature

Knockout MouseGeneticsGenetic EngineeringGenome EngineeringGenome Editing +6

p53 regulates a non-apoptotic death induced by ROS

Joan Montero, Chaitali Dutta, Diederik van Bodegom, +2

Cell Death and Differentiation

Non-apoptotic DeathApoptosisCell DeathTumor SuppressorMedicine +2

GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy

Lisa N. Kasiewicz, Souvik Biswas, Aaron Beach, +15

Nature Communications

NanoparticlesNanotherapeuticsEngineeringLipid NanoparticlesMolecular Biology +16

Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria

Cheng-Jung Lai, Natalie W. Pursell, Jessica J. Gierut, +15

Molecular Therapy

The Microphthalmia-associated Transcription Factor Requires SWI/SNF Enzymes to Activate Melanocyte-specific Genes

Ivana L. de la Serna, Yasuyuki Ohkawa, Chiduru Higashi, +5

Journal of Biological Chemistry

Transcriptional RegulationSystems BiologyDevelopmental BiologyMicrophthalmia Transcription FactorGenetics +13

Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1

Chaitali Dutta, Nicole Avitahl-Curtis, Natalie W. Pursell, +19

Molecular Therapy

The Induction of Acute Ileitis by a Single Microbial Antigen of <i>Toxoplasma gondii</i>

Nicolas Rachinel, Dominique Buzoni–Gatel, Chaitali Dutta, +7

The Journal of Immunology

The DNA Replication Checkpoint Directly Regulates MBF-Dependent G₁/S Transcription

Chaitali Dutta, Prasanta K. Patel, Adam P. Rosebrock, +2

Molecular and Cellular Biology

Transcriptional RegulationGenome InstabilityReplication CheckpointCell RegulationMolecular Regulation +11

BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death

Chaitali Dutta, Tovah A. Day, Nadja Kopp, +12

Cancer Research

Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2

Diederik van Bodegom, Jun Zhong, Nadja Kopp, +8

Blood