Ruth Thompson

Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo

Ryan Montano, Ruth Thompson, Injae Chung et al. · BMC Cancer · 2013 · 75 citations · Full text

A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase

Nandini Sakurikar, Ruth Thompson, Ryan Montano et al. · Oncotarget · 2015 · 74 citations · Full text

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus

Kiyohiro Ando, Melissa J. Parsons, Richa B. Shah et al. · The Journal of Cell Biology · 2017 · 67 citations · Full text

Genome Instability, Signal Transduction, Dna Damage +15

The Mre11 Nuclease Is Critical for the Sensitivity of Cells to Chk1 Inhibition

Ruth Thompson, Ryan Montano, Alan Eastman · PLoS ONE · 2012 · 55 citations · Full text

U2os Osteosarcoma Cells, Molecular Biology, Cell Death +19

An IRAK1–PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy

Peter H. Liu, Richa B. Shah, Yuanyuan Li et al. · Nature Cell Biology · 2019 · 53 citations

Radiation Medicine, Oncology, Radiation Therapy +9