Yisong Xiao

Lead identification of novel and selective TYK2 inhibitors

Jun Liang, Vickie Tsui, Anne van Abbema et al. · European Journal of Medicinal Chemistry · 2013 · 122 citations · Full text

Medicinal Chemistry, Hit Identification, Biochemistry +6

Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors

Jun Liang, Anne van Abbema, Mercedesz Balázs et al. · Journal of Medicinal Chemistry · 2013 · 97 citations · Full text

Pharmaceutical Research, Immunology, Lead Identification +24

Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors

Steven T. Staben, Jianwen A. Feng, Karen S. Lyle et al. · Journal of Medicinal Chemistry · 2014 · 63 citations · Full text

Compound 17, Structure-based Methods, Kinase Inhibitors +18

Identification of <i>C</i>-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2

Mark Zak, Christopher A. Hurley, Stuart I. Ward et al. · Journal of Medicinal Chemistry · 2013 · 61 citations · Full text

Pharmaceutical Science, Pharmacotherapy, Chemical Biology +19

Discovery and Optimization of <i>C</i>-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

Mark Zak, Rohan Mendonca, Mercedesz Balázs et al. · Journal of Medicinal Chemistry · 2012 · 61 citations · Full text

Pharmaceutical Science, Pharmacotherapy, Chemical Biology +16