Stuart I. Ward

Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors

Janusz J. Kulagowski, Wade Blair, Richard J. Bull et al. · Journal of Medicinal Chemistry · 2012 · 91 citations · Full text

Rheumatology, Medicinal Chemistry, Drug Target +15

Identification of <i>C</i>-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2

Mark Zak, Christopher A. Hurley, Stuart I. Ward et al. · Journal of Medicinal Chemistry · 2013 · 61 citations · Full text

Pharmaceutical Science, Pharmacotherapy, Chemical Biology +19

Discovery and Optimization of <i>C</i>-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

Mark Zak, Rohan Mendonca, Mercedesz Balázs et al. · Journal of Medicinal Chemistry · 2012 · 61 citations · Full text

Pharmaceutical Science, Pharmacotherapy, Chemical Biology +16

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy

Jack A. Terrett, Huifen Chen, Daniel G. Shore et al. · Journal of Medicinal Chemistry · 2021 · 49 citations · Full text

A reversed sulfonamide series of selective RORc inverse agonists

Monique B. van Niel, Benjamin P. Fauber, Matthew W. Cartwright et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 35 citations · Full text

Medicinal Chemistry, Biochemistry, Functional Selectivity +8