Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain

Samuel E. Marsh, Alec J. Walker, Tushar Kamath, +20

Nature Neuroscience

Neurodegenerative DiseasesGlial SignaturesNeuroanatomyMedicineSingle Cell Sequencing +10

PD-1 marks dysfunctional regulatory T cells in malignant gliomas

Daniel E. Lowther, Brittany A. Goods, Liliana E. Lucca, +10

JCI Insight

TIGIT signaling restores suppressor function of Th1 Tregs

Liliana E. Lucca, Pierre‐Paul Axisa, Emily Singer, +3

JCI Insight

T-regulatory CellImmune RegulationImmunologySignal RecognitionRegulatory T Cells +17

TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation

Andrea Pichler, Nadège Carrié, Marine Cuisinier, +23

Immunity

Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells

Liliana E. Lucca, Pierre‐Paul Axisa, Benjamin Y. Lu, +10

The Journal of Experimental Medicine

Tumor ImmunologyCancer ImmunosurveillanceTumor-exclusive T CellsT CellsT-regulatory Cell +13

Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme

Brittany A. Goods, Amanda Hernandez, Daniel E. Lowther, +7

PLoS ONE

Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS

Liliana E. Lucca, Benjamin A. Lerner, Calvin Park, +8

Neurology Neuroimmunology & Neuroinflammation

<i>In situ</i>expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS

Abdulraouf Ramadan, Liliana E. Lucca, Nadège Carrié, +6

Brain

Intermediate Filament ProteinImmune RegulationImmunologyImmunodominanceAntigen Processing +17

A multiple sclerosis–protective coding variant reveals an essential role for HDAC7 in regulatory T cells

Pierre‐Paul Axisa, Tomomi Yoshida, Liliana E. Lucca, +9

Science Translational Medicine

Bispecificity for Myelin and Neuronal Self-Antigens Is a Common Feature of CD4 T Cells in C57BL/6 Mice

Liliana E. Lucca, Sabine Desbois, Abdulraouf Ramadan, +9

The Journal of Immunology

T-regulatory CellImmunologyAntigen ProcessingCd4 T Cell ResponsesImmunotherapy +16