Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells

Tomokazu S. Sumida, Shai Dulberg, Jonas C. Schupp, +9

Nature Immunology

Transcriptional NetworkSignal TransductionAutoimmune DiseaseHuman T CellsMedicine +11

TIGIT signaling restores suppressor function of Th1 Tregs

Liliana E. Lucca, Pierre‐Paul Axisa, Emily Singer, +3

JCI Insight

T-regulatory CellImmune RegulationImmunologySignal RecognitionRegulatory T Cells +17

TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation

Andrea Pichler, Nadège Carrié, Marine Cuisinier, +23

Immunity

Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells

Liliana E. Lucca, Pierre‐Paul Axisa, Benjamin Y. Lu, +10

The Journal of Experimental Medicine

Tumor ImmunologyCancer ImmunosurveillanceTumor-exclusive T CellsT CellsT-regulatory Cell +13

Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis

Hiromitsu Asashima, Pierre‐Paul Axisa, Thi Hong Giang Pham, +7

Journal of Clinical Investigation

T-regulatory CellImmunologyImmune RegulationPathologyCd4 T Cell Responses +15

Podoplanin is a negative regulator of Th17 inflammation

Alyssa Nylander, Gerald Ponath, Pierre‐Paul Axisa, +5

JCI Insight

Genetic mapping across autoimmune diseases reveals shared associations and mechanisms

Matthew R. Lincoln, Noah Connally, Pierre‐Paul Axisa, +50

Nature Genetics

ImmunogeneticsAutoimmune DiseaseAutoantibody ProductionDisease EtiologyGenetics +8

<i>In situ</i>expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS

Abdulraouf Ramadan, Liliana E. Lucca, Nadège Carrié, +6

Brain

Intermediate Filament ProteinImmune RegulationImmunologyImmunodominanceAntigen Processing +17

The tidyomics ecosystem: enhancing omic data analyses

William Hutchison, Timothy Keyes, Helena L. Crowell, +28

Nature Methods

Functional GenomicsOmics DatasetsTidyomics EcosystemOmicsGenomics +4

A multiple sclerosis–protective coding variant reveals an essential role for HDAC7 in regulatory T cells

Pierre‐Paul Axisa, Tomomi Yoshida, Liliana E. Lucca, +9

Science Translational Medicine