Christopher S. Theile

Author

Whitehead Institute for Biomedical Research

Also Known As

Christopher S Theile, Christopher S. Theile, Christopher Theile, Christopher S Theile, Theile, C.S.

Publications

2.1K

Citations

H-Index

Concepts

All Affiliations

Whitehead Institute for Biomedical Research Massachusetts Institute of Technology Alnylam Pharmaceuticals (United States)Harvard University Howard Hughes Medical Institute

About

Christopher S. Theile is an author at Whitehead Institute for Biomedical Research specializing in natural sciences, medicine, and molecular biology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Natural Sciences	8	8	1.2K
2	Medicine	7	7	756
3	Biochemistry	6	6	567
4	Biomolecular Engineering	3	3	236
5	Engineering	2	2	151

Christopher S. Theile

Publications

Citations

H-Index

Page 1

	Year	Citations
Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions Carla P. Guimarães, Martin D. Witte, Christopher S. Theile, Nature Protocols Protein AssemblyBiochemistryProtein FoldingNatural SciencesMolecular Biology	2013	350
Site-specific N-terminal labeling of proteins using sortase-mediated reactions Christopher S. Theile, Martin D. Witte, Annet E. M. Blom, Nature Protocols Natural SciencesMolecular BiologyMolecular SortingProtein EngineeringProteomics	2013	274
Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates Christopher R. Brown, Swati Gupta, June Qin, Nucleic Acids Research Sirna AccumulationMolecular PharmacologyMedicinal ChemistryPharmaceutical ScienceFunctional Sirna	2020	265
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates Kirk Brown, Jayaprakash K. Nair, Maja M. Janas, Nature Biotechnology Rnai TherapeuticsLiver PhysiologyGene DeliveryAntisense TherapyTherapeutics	2022	225
5′‐(<i>E</i>)‐Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA–GalNAc Conjugates Rubina Parmar, Jennifer L. S. Willoughby, Jingxuan Liu, ChemBioChem	2016	132
siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2 Elad Elkayam, Rubina Parmar, Christopher R. Brown, Nucleic Acids Research Un-modified SirnaTranscriptional RegulationCrystal Structure-Vinylphosphonate MoietyEnhanced Binding	2016	85
Production of unnaturally linked chimeric proteins using a combination of sortase-catalyzed transpeptidation and click chemistry Martin D. Witte, Christopher S. Theile, Tongfei Wu, Nature Protocols Chimeric ProteinsBiosynthesisSortase-catalyzed TranspeptidationEngineeringBiochemistry	2013	76
Site-specific protein modification using immobilized sortase in batch and continuous-flow systems Martin D. Witte, Tongfei Wu, Carla P. Guimarães, Nature Protocols EngineeringProtein FoldingContinuous-flow SystemsBiotechnologyMolecular Sorting	2015	75
Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells Ana M. Avalos, Angelina M. Bilate, Martin D. Witte, The Journal of Experimental Medicine Molecular ImmunologySignal TransductionMonovalent EngagementAdaptive Immune SystemCell Signaling	2014	62
Site-Specific Chemoenzymatic Labeling of Aerolysin Enables the Identification of New Aerolysin Receptors Irene Wuethrich, Janneke G. C. Peeters, Annet E. M. Blom, PLoS ONE Drug TargetToxinologyGlycobiologyMolecular BiologySite-specific Chemoenzymatic Labeling	2014	55

Page 1