Emmanuelle Proust

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: Design, synthesis and structure–activity relationship studies

Fabrice Vergne, Patrick Bernardelli, Edwige Lorthiois et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 57 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1

Edwige Lorthiois, Patrick Bernardelli, Fabrice Vergne et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 50 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives

Patrick Bernardelli, Edwige Lorthiois, Fabrice Vergne et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 38 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: Metabolism-directed optimization studies towards orally bioavailable derivatives

Fabrice Vergne, Patrick Bernardelli, Edwige Lorthiois et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 36 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14