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Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: Metabolism-directed optimization studies towards orally bioavailable derivatives

Novel Structural ClassMedicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug DesignSelective Pde7 InhibitorsDrug DevelopmentPharmacologyMetabolism-directed Optimization StudiesDrug Discovery