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Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: Design, synthesis and structure–activity relationship studies

Fabrice Vergne, Patrick Bernardelli, Edwige Lorthiois, Nga Pham, Emmanuelle Proust, Chrystelle Oliveira, Abdel‐Kader Mafroud, Frédérique Royer, Roger Wrigglesworth, Jennifer Schellhaas,

Bioorganic & Medicinal Chemistry Letters · 2004 · 57 citations · 16 references

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16

Identification and Characterization of a Novel Family of Cyclic Nucleotide Phosphodiesterases

Scott H. Soderling, Sharon J. Bayuga, Joseph A. Beavo · Journal of Biological Chemistry · 1998 · 288 citations · Full text

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CD3- and CD28-Dependent Induction of PDE7 Required for T Cell Activation

Linsong Li, Cassian Yee, Joseph A. Beavo · Science · 1999 · 256 citations

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Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer’s disease brains examined by in situ hybridization

S. Pérez-Torres, Roser Cortés, Markus Tolnay et al. · Experimental Neurology · 2003 · 133 citations

, , +17

Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells

Susan J. Smith, Steven Brookes-Fazakerley, Louise Donnelly et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2003 · 121 citations

, , +10

Differential distribution of cAMP‐specific phosphodiesterase 7A mRNA in rat brain and peripheral organs

Xavier Miró, S. Pérez-Torres, José Palacios et al. · Synapse · 2001 · 99 citations

, , +11