Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors

Noel D. D’Angelo, Tae‐Seong Kim, Kristin L. Andrews, +25

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyBenzothiazole Phosphoinositide 3-KinaseChemical BiologyPharmaceutical Chemistry +19

Combretastatin A4 Nanodrug‐Induced MMP9 Amplification Boosts Tumor‐Selective Release of Doxorubicin Prodrug

Jian Jiang, Na Shen, Tianyuan Ci, +4

Advanced Materials

Mmp9-dox-nps ExhibitsTumor Hypoxia StateOncologyNanotherapeuticsDoxorubicin Prodrug +12

Knockdown of the oncogene lncRNA NEAT1 restores the availability of <i>miR-34c</i> and improves the sensitivity to cisplatin in osteosarcoma

Yuliang Hu, Qiuyong Yang, Long Wang, +4

Bioscience Reports

Combining disulfiram and poly(l-glutamic acid)-cisplatin conjugates for combating cisplatin resistance

Wantong Song, Zhaohui Tang, Na Shen, +7

Journal of Controlled Release

Cisplatin ResistanceChromatinMedicinal ChemistryHealth SciencesPolymer-drug Conjugate +7

Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

Mark H. Norman, Kristin L. Andrews, Yunxin Bo, +34

Journal of Medicinal Chemistry

Chemoprevention StrategyMolecular BiologyClinical CandidatePharmacotherapyChemical Biology +17

Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

Adrian L. Smith, Noel D. D’Angelo, Yunxin Bo, +29

Journal of Medicinal Chemistry

Structure–Activity Relationships of Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Investigations of Various 6,5-Heterocycles to Improve Metabolic Stability

Markian M. Stec, Kristin L. Andrews, Shon K. Booker, +15

Journal of Medicinal Chemistry

Vitro PotencyPharmaceutical ScienceDrug TargetPharmacotherapyImidazopyridazine 10 +17

Hsa_Circ_0007843 Acts as a mIR-518c-5p Sponge to Regulate the Migration and Invasion of Colon Cancer SW480 Cells

Jin He, Ze Ping Han, Jin Luo, +8

Frontiers in Genetics

MiR-1281, a p53-responsive microRNA, impairs the survival of human osteosarcoma cells upon ER stress via targeting USP39.

Jian Jiang, Binbin Ma, Xiaojie Li, +4

PubMed

MicroRNA-497 inhibits multiple myeloma growth and increases susceptibility to bortezomib by targeting Bcl-2

Faqing Tian, Yong Zhan, Zhu Wei, +3

International Journal of Molecular Medicine

Hematological MalignancyTumor BiologyMedicineMm Cell ProliferationMalignant Blood Disorder +11