Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin

Chengbin Wu, Ying Hua, Christine Grinnell, +16

Nature Biotechnology

Systems BiologyEngineeringAllergyImmunoengineeringImmunology +9

Comparisons of affinities, avidities, and complement activation of adalimumab, infliximab, and etanercept in binding to soluble and membrane tumor necrosis factor

Zehra Kaymakcalan, Paul Sakorafas, Sahana Bose, +5

Clinical Immunology

InflammationComplement SystemAnti-inflammatoryAutoimmune DiseaseImmunology +6

Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

Jennifer Dumont, Tongyao Liu, Susan C. Low, +13

Blood

Characterization of Noncovalent Complexes of Recombinant Human Monoclonal Antibody and Antigen Using Cation Exchange, Size Exclusion Chromatography, and BIAcore

Ling C. Santora, Zehra Kaymakcalan, Paul Sakorafas, +2

Analytical Biochemistry

ImmunohematologyNoncovalent ComplexesBiochemistryBioanalysisImmunology +9

Establishing <i>in vitro in vivo</i> correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

Lindsay B. Avery, Jason Wade, Mengmeng Wang, +18

mAbs

Immunocytochemical TechniqueImmunologyPathologyImmunotherapyImmunological Biomarkers +19

LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes.

Burkhart Schraven, David S. Schoenhaut, Eddy Bruyns, +7

Journal of Biological Chemistry

T-regulatory CellImmunologyImmune RegulationImmunologic MechanismAntigen Processing +16

Small-molecule control of antibody N-glycosylation in engineered mammalian cells

Michelle Chang, Leonid Gaidukov, Giyoung Jung, +17

Nature Chemical Biology

EngineeringMedicineAntibody N-glycosylationGlycobiologySynthetic Biology +6

IL-18 Receptor β-Induced Changes in the Presentation of IL-18 Binding Sites Affect Ligand Binding and Signal Transduction

Chengbin Wu, Paul Sakorafas, Renee Miller, +4

The Journal of Immunology

Oligoclonality of rheumatoid factors arising spontaneously in lpr/lpr mice

Claudia B. Wolfowicz, Paul Sakorafas, Thomas L. Rothstein, +1

Clinical Immunology and Immunopathology

InflammationRheumatologyRheumatoid DisorderAutoimmune DiseaseRheumatic Diseases +8

X-ray Crystal Structures of Monomeric and Dimeric Peptide Inhibitors in Complex with the Human Neonatal Fc Receptor, FcRn

Adam R. Mezo, Vandana Sridhar, John Badger, +2

Journal of Biological Chemistry