Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin

Chengbin Wu, Ying Hua, Christine Grinnell, +16

Nature Biotechnology

Systems BiologyEngineeringAllergyImmunoengineeringImmunology +9

RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury

Andrea J. Mothe, Nardos G. Tassew, Alirezha P. Shabanzadeh, +9

Scientific Reports

Pain MedicineImmunologyNeuropathic PainHuman Monoclonal AntibodiesNeuroinflammation +18

Studies in serum support rapid formation of disulfide bond between unpaired cysteine residues in the VH domain of an immunoglobulin G1 molecule

David Ouellette, Leslie Alessandri, Adam T. Chin, +4

Analytical Biochemistry

Protein ChemistryImmunoglobulin G1 MoleculeProtein FunctionDisulfide BondProtein Assembly +9

Targeting Anti–TGF-β Therapy to Fibrotic Kidneys with a Dual Specificity Antibody Approach

Steve McGaraughty, Rachel Davis‐Taber, Chang Zhu, +14

Journal of the American Society of Nephrology

Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates

Peer B. Jacobson, Robin J Goody, Matthew S. Lawrence, +23

Neurobiology of Disease

Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration

Kun Ding, Lucia J. Eaton, Diana R. Bowley, +23

mAbs

Translational MedicineOcular DiseaseAngiogenesisNeutralizes VegfOphthalmology +10

Arabinosylation of recombinant human immunoglobulin-based protein therapeutics

Patrick Hossler, Christopher Chumsae, Christopher Racicot, +11

mAbs

Protein GlycosylationHigh Mannose GlycansNatural SciencesImmunologyGlycobiology +12

A 13C NMR approach to categorizing potential limitations of α,β-unsaturated carbonyl systems in drug-like molecules

Kevin P. Cusack, Lee D. Arnold, Claude Barberis, +8

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineBiomolecular AnalysisRational Drug DesignNmr Approach +4

Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig

Philip D. Bardwell, Matthew Staron, Junjian Liu, +15

Protein & Cell

Cell TherapyHalf Dvd-ig MoleculesImmunologyCell DeathTumor Cells +15