Studies in serum support rapid formation of disulfide bond between unpaired cysteine residues in the VH domain of an immunoglobulin G1 molecule

Characterizing biological products and assessing comparability following manufacturing changes

Arthur J. Chirino, Anthony R. Mire‐Sluis · Nature Biotechnology · 2004 · 361 citations

Biomanufacturing, Engineering, Agricultural Economics +8

Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass

Thomas M. Dillon, Margaret Speed Ricci, Chris Vezina et al. · Journal of Biological Chemistry · 2008 · 289 citations · Full text

Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms

Jette Wypych, Ming Li, Amy Guo et al. · Journal of Biological Chemistry · 2008 · 279 citations · Full text

Covalent Structure, Autoimmune Disease, Immunology +10

A technique for the removal of pyroglutamic acid from the amino terminus of proteins using calf liver pyroglutamate amino peptidase

David N. Podell, G N Abraham · Biochemical and Biophysical Research Communications · 1978 · 252 citations

Biochemistry, Medicine, Natural Sciences +6

Formation of Pyroglutamic Acid from N-Terminal Glutamic Acid in Immunoglobulin Gamma Antibodies

Dirk Chelius, Kay Jing, Alexis M. K. Lueras et al. · Analytical Chemistry · 2006 · 199 citations

Immunocytochemical Technique, Immunology, Glycobiology +23