Gareth Wayne

Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production <i>in vivo</i>

Ishrut Hussain, Julie A. Hawkins, David C. Harrison et al. · Journal of Neurochemistry · 2006 · 198 citations

Molecular Pharmacology, Alzheimer's Disease, Biochemistry +13

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase

Zoe Scholefield, Edwin A. Yates, Gareth Wayne et al. · The Journal of Cell Biology · 2003 · 179 citations · Full text

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

André Mateus, Laurie Gordon, Gareth Wayne et al. · Proceedings of the National Academy of Sciences · 2017 · 87 citations · Full text

Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability

Laurie Gordon, Morven Allen, Per Artursson et al. · SLAS DISCOVERY · 2015 · 67 citations · Full text

Cellular Assays, Biological Mass Spectrometry, Lead Identification +25

TIMP-3 Inhibition of ADAMTS-4 (Aggrecanase-1) Is Modulated by Interactions between Aggrecan and the C-terminal Domain of ADAMTS-4

Gareth Wayne, Su-Jun Deng, Augustin Amour et al. · Journal of Biological Chemistry · 2007 · 65 citations · Full text

Molecular Biology, Chemical Biology, Free Adamts-4 +19