Christopher J. Stubbs

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

Nicolas Béry, Sandrine Legg, J.E. Debreczeni et al. · Nature Communications · 2019 · 96 citations · Full text

Medicine, Molecular Biology, Oncology +17

Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies

Nicola Lawson, Carly I. Dix, Paul W. Scorer et al. · Modern Pathology · 2019 · 87 citations · Full text

Medicine, Immunology, Oncology +17

Using Ligand‐Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo‐Like Kinase 1

Yaw Sing Tan, P. Sledz, Steffen Lang et al. · Angewandte Chemie International Edition · 2012 · 83 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Specific inhibition of CK2α from an anchor outside the active site

P. Brear, Claudia De Fusco, Kathy Hadje Georgiou et al. · Chemical Science · 2016 · 73 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo‐Like Kinase 1

P. Sledz, Christopher J. Stubbs, Steffen Lang et al. · Angewandte Chemie International Edition · 2011 · 71 citations · Full text

Life Sciences, Biochemistry, Biophysics +17