The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Saul Villeda, Jian Luo, Kira I. Mosher, +20

Nature

Alzheimer's DiseaseDevelopmental BiologyAgingDevelopmental Cognitive NeuroscienceLongevity +9

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

Gernot Kleinberger, Yoshinori Yamanishi, Marc Suárez‐Calvet, +29

Science Translational Medicine

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

Kurt M. Lucin, Caitlin E. O’Brien, Gregor Bieri, +8

Neuron

ImmunologyCell DeathMicroglial Beclin 1Alzheimer ’Social Sciences +15

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease

Jinte Middeldorp, Benoit Lehallier, Saul Villeda, +9

JAMA Neurology

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

Eva Czirr, Nicholas A. Castello, Kira I. Mosher, +13

The Journal of Experimental Medicine

Autoimmunity contributes to nociceptive sensitization in a mouse model of complex regional pain syndrome

Wen‐Wu Li, Tian‐Zhi Guo, Xiaoyou Shi, +6

Pain

Acute PainPain MedicineImmunologyImmune RegulationNeuropathic Pain +18

Outer dense fibre protein 2 (ODF2) is a self-interacting centrosomal protein with affinity for microtubules

Fatima F. Donkor, Maren Mönnich, Eva Czirr, +2

Journal of Cell Science

OocyteMicrotubule NucleationMolecular BiologyCytoskeletonReproductive Biology +17

Independent Generation of Aβ42 and Aβ38 Peptide Species by γ-Secretase

Eva Czirr, Barbara A. Cottrell, Stefanie Leuchtenberger, +12

Journal of Biological Chemistry

α‐secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation

Sebastian Jäger, Stefanie Leuchtenberger, Anne Marie Martin, +9

Journal of Neurochemistry

Neurodegenerative DiseasesProtein SecretionAlzheimer's DiseaseBiochemistryNatural Sciences +13

Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer’s disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure

Stefanie Hahn, Tanja Brüning, Eva Czirr, +6

Journal of Neurochemistry

Synaptic TransmissionNeurochemical Biomarkersγ-Secretase ModulatorsSynaptic SignalingSocial Sciences +16