Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

Julia Marschallinger, Tal Iram, Macy E. Zardeneta, +15

Nature Neuroscience

Alzheimer's DiseaseAgingMedicineDementiaBrain-immune Interaction +10

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

Nicole Almanzar, Jane Antony, Ankit S. Baghel, +131

Nature

Cell LineageDevelopmental BiologySingle-cell Transcriptomic AtlasSingle Cell SequencingMedicine +6

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

David Gate, Naresha Saligrama, Olivia Leventhal, +18

Nature

Neurodegenerative DiseasesAlzheimer's DiseaseCd8 T CellsMedicineCerebrospinal Fluid +9

Undulating changes in human plasma proteome profiles across the lifespan

Benoit Lehallier, David Gate, Nicholas Schaum, +12

Nature Medicine

Lifespan ExtensionProteomic TechnologyDevelopmental BiologyAgingLongevity +6

Ageing hallmarks exhibit organ-specific temporal signatures

Nicholas Schaum, Benoit Lehallier, Oliver Hãhn, +158

Nature

Signal TransductionAgingDevelopmental BiologyLongevityCellular Senescence +5

An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

Nazish Sayed, Yingxiang Huang, Khiem Nguyen, +23

Nature Aging

InflammationEngineeringAgingDeep LearningLongevity +7

Organ aging signatures in the plasma proteome track health and disease

Hamilton Oh, Jarod Rutledge, Daniel Nachun, +33

Nature

Physiological blood–brain transport is impaired with age by a shift in transcytosis

Andrew C. Yang, Marc Y. Stevens, Michelle B. Chen, +25

Nature

AgingPhysiological Blood–brain TransportNeurophysiologyPhysiologyBrain-immune Interaction +7

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

Hanadie Yousef, Cathrin J. Czupalla, Davis Lee, +19

Nature Medicine

Neurodegenerative DiseasesAlzheimer's DiseaseAgingMedicineDementia +12

Exercise plasma boosts memory and dampens brain inflammation via clusterin

Zurine De Miguel, Nathalie Khoury, Michael J. Betley, +20

Nature

Health SciencesExercise PlasmaExerciseMedicineExercise Physiology +7