Haruhide Kimura

De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions

Niccolò E. Mencacci, Erik-Jan Kamsteeg, Kosuke Nakashima et al. · The American Journal of Human Genetics · 2016 · 117 citations · Full text

TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in mice

Hiroshi Yukitake, Tatsuhiko Fujimoto, Takashi Ishikawa et al. · Pharmacology Biochemistry and Behavior · 2019 · 93 citations

Molecular Physiology, Signal Transduction, Functional Selectivity +11

Orexin 2 receptor–selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients

Rebecca Evans, Haruhide Kimura, Robert Alexander et al. · Proceedings of the National Academy of Sciences · 2022 · 85 citations · Full text

Sleep Disorders, Narcolepsy Phenotype, Pharmacotherapy +19

A homozygous <i>loss‐of‐function</i> mutation in <i>PDE2A</i> associated to early‐onset hereditary chorea

Vincenzo Salpietro, Belén Pérez‐Dueñas, Kosuke Nakashima et al. · Movement Disorders · 2018 · 67 citations · Full text

Discovery of 1-[2-Fluoro-4-(1<i>H</i>-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1<i>H</i>-pyrazol-5-yl)pyridazin-4(1<i>H</i>)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor

Jun Kunitomo, Masato Yoshikawa, Makoto Fushimi et al. · Journal of Medicinal Chemistry · 2014 · 64 citations

Pharmaceutical Science, Pharmacotherapy, Pharmaceutical Chemistry +19