Marika Nespi

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

Elizabeth E. Spangenberg, Paul Severson, Lindsay A. Hohsfield et al. · Nature Communications · 2019 · 998 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

RAF inhibitors that evade paradoxical MAPK pathway activation

Chao Zhang, Wayne Spevak, Ying Zhang et al. · Nature · 2015 · 381 citations

Life Sciences, Cancer Biology, Oncology +14

BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor

Hatice Gülçin Özer, Dalia El‐Gamal, Ben Powell et al. · Cancer Discovery · 2018 · 138 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor

Chao Zhang, Prabha N. Ibrahim, Jiazhong Zhang et al. · Proceedings of the National Academy of Sciences · 2013 · 95 citations · Full text

Medicine, Oncology, Pharmacology +12

Overcoming Preclinical Safety Obstacles to Discover (<i>S</i>)-<i>N</i>-((1,2,3,5,6,7-Hexahydro-<i>s</i>-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5<i>H</i>-pyrazolo[5,1-<i>b</i>][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

Christopher McBride, Lynnie Trzoss, Davide Povero et al. · Journal of Medicinal Chemistry · 2022 · 73 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17