Roland Blanqué

Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2- <i>a</i> ]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis

Nicolas Desroy, Christopher Housseman, Xavier Bock et al. · Journal of Medicinal Chemistry · 2017 · 139 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +8

A TNF receptor loop peptide mimic blocks RANK ligand–induced signaling, bone resorption, and bone loss

Kazuhiro Aoki, Hiroaki Saito, Cécile Itzstein et al. · Journal of Clinical Investigation · 2006 · 138 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic

Mathieu Pizzonero, Sonia Dupont, Marielle Babel et al. · Journal of Medicinal Chemistry · 2014 · 110 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Targeting of αv-Integrins in Stem/Progenitor Cells and Supportive Microenvironment Impairs Bone Metastasis in Human Prostate Cancer

Geertje van der Horst, Christel van den Hoogen, Jeroen T. Buijs et al. · Neoplasia · 2011 · 107 citations · Full text

Medicine, Molecular Biology, Oncology +17

Hypothermia as an indicator of the acute effects of lipopolysaccharides: comparison with serum levels of IL1β, IL6 and TNFα

Roland Blanqué, C. Meakin, S. Millet et al. · General Pharmacology The Vascular System · 1996 · 67 citations

Life Sciences, Immunology, Physiology +6