Adam Flegg

Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1

Andrew D. Napper, Jeffrey Hixon, Thomas McDonagh et al. · Journal of Medicinal Chemistry · 2005 · 525 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction

Stephen P. East, Samantha J. Bamford, Matthias G. A. Dietz et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 46 citations · Full text

Medicine, Neuroscience, Pharmacology +11

Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein Inhibitors: Discovery of 2-[4-(3-{(<i>R</i>)-1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-<i>N</i>,<i>N</i>-dimethyl-acetamide (BI 665915)

Hidenori Takahashi, Doris Riether, Alessandra Bartolozzi et al. · Journal of Medicinal Chemistry · 2015 · 36 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties

Neil Moss, Younggi Choi, Derek A. Cogan et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 25 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +11