Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ

Lloyd G. Czaplewski, Ian Collins, Edward A. Boyd, +16

Bioorganic & Medicinal Chemistry Letters

Inhibitory ActivityBiochemistryMedicineNatural SciencesAntibacterial Alkoxybenzamide Inhibitors +8

DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity

Stephen P. East, Clara Bantry White, Oliver Barker, +22

Bioorganic & Medicinal Chemistry Letters

Inhibitory ActivityMedicineAntibacterial ActivityAntibacterial AgentAntimicrobial Chemotherapy +6

An in Silico Method for Predicting Ames Activities of Primary Aromatic Amines by Calculating the Stabilities of Nitrenium Ions

Jörg Bentzien, Eugene R. Hickey, Raymond A. Kemper, +4

Journal of Chemical Information and Modeling

EngineeringNitrenium HypothesisChemical AnalysisMolecular BiologyOrganic Chemistry +14

An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction

Stephen P. East, Samantha J. Bamford, Matthias G. A. Dietz, +15

Bioorganic & Medicinal Chemistry Letters

Motor DysfunctionMglu4 ReceptorMedicinePhysiologyAnimal Model +5

The Azulene-to-Naphthalene Rearrangement Revisited:  a DFT Study of Intramolecular and Radical-Promoted Mechanisms

Roger W. Alder, Stephen P. East, Jeremy N. Harvey, +1

Journal of the American Chemical Society

Activation EnergyCombinatorial ChemistryEngineeringHeterocyclicBiochemistry +12

Design and synthesis of substituted pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors

Namal C. Warshakoon, Shengde Wu, Angelique Boyer, +11

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryDerivative (Chemistry)BiochemistryMedicine +8

Structure–activity relationships of the peptide deformylase inhibitor BB-3497: modification of the metal binding group

Helen K. Smith, R. Paul Beckett, John M. Clements, +8

Bioorganic & Medicinal Chemistry Letters

Protein ChemistryBiochemistryNatural SciencesMetalloproteinMolecular Biology +2

Midazolam: kinetics and effects on memory, sensorium, and haemodynamics.

Stéphanie Langlois, JH Kreeft, G Chouinard, +3

British Journal of Clinical Pharmacology

Drug SafetyNeurophysiologyMedicineAnesthetic MechanismPsychopharmacology +12

Total synthesis of the cyclopeptide alkaloid sanjoinine G1 and its C-11 epimer

Stephen P. East, Feng Shao, Lorenzo Williams, +1

Tetrahedron

Pharmaceutical ChemistryHeterocyclicAlkene MetathesisBiochemistrySchmidt Protocol +9

Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity

Monika Ermann, Doris Riether, Edward R. Walker, +15

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyDrug TargetCb2 SelectivityFunctional SelectivityMedicine +7