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A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties

Neil Moss, Younggi Choi, Derek A. Cogan, Adam Flegg, Andreas F. Kahrs, Pui L. Loke, Orietta Meyn, Raj Nagaraja, Spencer Napier, Ashley Parker,

Bioorganic & Medicinal Chemistry Letters · 2009 · 25 citations · 15 references

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The importance of plasma protein binding in drug discovery

George L. Trainor · Expert Opinion on Drug Discovery · 2007 · 336 citations

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Ablation of Serotonin 5-HT<sub>2B</sub>Receptors in Mice Leads to Abnormal Cardiac Structure and Function

Canan G. Nebigil, Pierre Hickel, Nadia Messaddeq et al. · Circulation · 2001 · 141 citations

Overexpression of the Serotonin 5-HT <sub>2B</sub> Receptor in Heart Leads to Abnormal Mitochondrial Function and Cardiac Hypertrophy

Canan G. Nebigil, Fabrice Jaffré, Nadia Messaddeq et al. · Circulation · 2003 · 139 citations

Attenuation of haloperidol‐induced catalepsy by a 5‐HT<sub>2C</sub> receptor antagonist

C. Reavill, Anthony J. Kettle, Vicky Holland et al. · British Journal of Pharmacology · 1999 · 132 citations · Full text

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Involvement of the Serotonin 5-HT <sub>2B</sub> Receptor in Cardiac Hypertrophy Linked to Sympathetic Stimulation

Fabrice Jaffré, Jacques Callebert, Alexandre Sarre et al. · Circulation · 2004 · 128 citations · Full text