Involvement of the Serotonin 5-HT _2B Receptor in Cardiac Hypertrophy Linked to Sympathetic Stimulation

Abstract

Our results demonstrate for the first time that 5-HT2B receptors are essential for isoproterenol-induced cardiac hypertrophy, which involves the regulation of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by cardiac fibroblasts.