Spencer Napier

Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck:  Synthesis, SAR, and in Vivo Antiinflammatory Activity

Matthew W. Martin, John Newcomb, Joseph J. Nunes et al. · Journal of Medicinal Chemistry · 2006 · 61 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Palladium-catalysed cross-coupling of 2-trimethylsilylpyridine with aryl halides

Spencer Napier, Sebastian M. Marcuccio, Heather Tye et al. · Tetrahedron Letters · 2008 · 39 citations

Natural Sciences, Chemistry, Catalysis +10

A robust method for the Hiyama-type coupling of arylsiloxanes and disiloxanes with aryl halides

Spencer Napier, Sebastian M. Marcuccio, Heather Tye et al. · Tetrahedron Letters · 2008 · 37 citations

Natural Sciences, Chemistry, Organic Chemistry +9

Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein Inhibitors: Discovery of 2-[4-(3-{(<i>R</i>)-1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-<i>N</i>,<i>N</i>-dimethyl-acetamide (BI 665915)

Hidenori Takahashi, Doris Riether, Alessandra Bartolozzi et al. · Journal of Medicinal Chemistry · 2015 · 36 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties

Neil Moss, Younggi Choi, Derek A. Cogan et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 25 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +11