TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling

Harald J. Junge, Stacey C. Yang, Jeremy B. Burton, +6

Cell

Ocular DiseaseDevelopmental BiologySignal TransductionOphthalmologySignaling Pathway +9

A Novel Tankyrase Small-Molecule Inhibitor Suppresses <i>APC</i> Mutation–Driven Colorectal Tumor Growth

Ted Lau, Emily Chan, Marinella Callow, +15

Cancer Research

Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

Eric Bourhis, Christine Tam, Yvonne Franke, +6

Journal of Biological Chemistry

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

Marinella Callow, Hoanh Tran, Lilian Phu, +12

PLoS ONE

Molecular RegulationAxin ScaffoldingRnf146 Protein LevelsTranscriptional RegulationSignaling Pathway +18

Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis

Hua Tian, Brian Biehs, Cecilia Chiu, +5

Cell Reports

Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies

Yan Gong, Eric Bourhis, Cecilia Chiu, +13

PLoS ONE

Environmental SignalingMolecular RegulationImmunologyCell CultureCellular Physiology +19

Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

Eric Bourhis, Weiru Wang, Christine Tam, +14

Structure

Signal TransductionBiochemistryMedicinePeptide LibraryPeptide Therapeutic +8

Inhibition of Wnt signaling by Dishevelled PDZ peptides

Yingnan Zhang, B.A. Appleton, Christian Wiesmann, +4

Nature Chemical Biology

Signal TransductionSignaling PathwayMedicineReceptor Tyrosine KinaseDishevelled Pdz Peptides +2

Hyperactivation of the <i>folded gastrulation</i> pathway induces specific cell shape changes

Pierre Morize, Audrey E. Christiansen, Mike Costa, +2

Development

Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index &lt; 1

Yu Zhong, Paula Katavolos, Tien‐Trung Nguyen, +9

Toxicologic Pathology

Gastrointestinal PharmacologyGastroenterologyPathologyWnt SignalingDigestive Tract +14