The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

Issam Ben Sahra, Kathiane Laurent, Agnès Loubat, +6

Oncogene

Cyclin D1 LevelAntidiabetic Drug MetforminAntitumoral EffectDiabetes ManagementInsulin Management +6

A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.

Kohei Miyazono, Anders Olofsson, Pascal Colosetti, +1

The EMBO Journal

Signal TransductionMolecular PhysiologyDevelopmental BiologySignaling PathwayReceptor Tyrosine Kinase +7

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function

Frédéric Luciano, Arnaud Jacquel, Pascal Colosetti, +4

Oncogene

Protein FunctionSignal TransductionBiochemistryMedicineSerine 69 +9

Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes.

Anders Olofsson, Kohei Miyazono, Tetsuto Kanzaki, +3

Journal of Biological Chemistry

Different Tgf-beta IsoformsImmunologyCell GrowthCancer BiologyGlioma +17

Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis

Magali Herrant, Arnaud Jacquel, Sandrine Marchetti, +4

Oncogene

Signal TransductionCell RegulationMedicineApoptosisImmunology +5

Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux

Sandy Giuliano, Yann Cormerais, Maeva Dufies, +11

Autophagy

Proteasome InhibitorsAutophagic FluxMedicineAutophagyPharmacology +11

Use of Nanovesicles from Orange Juice to Reverse Diet-Induced Gut Modifications in Diet-Induced Obese Mice

Pascal Colosetti, Audrey Jalabert, Emmanuelle Meugnier, +11

Molecular Therapy — Methods & Clinical Development

Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line

Pascal Colosetti, Alexandre Puissant, Guillaume Robert, +5

Autophagy

Multicentric evaluation of the MDR phenotype in leukemia

JP Marie, Sylvie Huet, A‐M Faussat, +41

Leukemia

Hematological MalignancyMedicineMixed-phenotype Acute LeukemiaPathologyMolecular Diagnostics +4

A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis

Arnaud Jacquel, Magali Herrant, Virginie Defamie, +9

Oncogene

ChromatinNatural SciencesMixed-phenotype Acute LeukemiaMegakaryocytic DifferentiationSignaling Pathways +6