Behnoush Hajian

Discovery of a structural class of antibiotics with explainable deep learning

Felix Wong, Erica J. Zheng, Jacqueline A. Valeri et al. · Nature · 2023 · 356 citations · Full text

Antimicrobial Drug Discovery, Antimicrobial Resistance Gene, Antibiotics +12

Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex

Jason J. Kwon, Behnoush Hajian, Yuemin Bian et al. · Nature · 2022 · 82 citations · Full text

Biochemistry, Protein Assembly, Natural Sciences +6

An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with <i>In Vivo</i> Efficacy against Drug-Resistant Gram-Negative Infections

Erica N. Parker, Brett N. Cain, Behnoush Hajian et al. · ACS Central Science · 2022 · 71 citations · Full text

Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents

Behnoush Hajian, Eric W. Scocchera, Carolyn Shoen et al. · Cell chemical biology · 2019 · 66 citations · Full text

Pulmonary Tuberculosis, Drug Target, Biochemistry +11

Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens

Eric W. Scocchera, Stephanie M. Reeve, Santosh Keshipeddy et al. · ACS Medicinal Chemistry Letters · 2016 · 36 citations · Full text

Classical Antifolates, Bioorganic Chemistry, Molecular Biology +19