Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

Rita Sulahian, Jason J. Kwon, Katherine H. Walsh, +28

Cell Reports

Synthetic Lethal InteractionShoc2 DepletionCancer BiologyTumor BiologySignaling Pathway +15

Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex

Jason J. Kwon, Behnoush Hajian, Yuemin Bian, +22

Nature

BiochemistryProtein AssemblyNatural SciencesProtein X-ray CrystallographyMolecular Biology +4

Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential

Jason J. Kwon, Jeffrey A. Willy, Kayla Quirin, +4

Oncotarget

Therapeutic PotentialImmunologyPathologyCell DeathCancer Biology +16

Pathophysiological role of microRNA-29 in pancreatic cancer stroma

Jason J. Kwon, Sarah C. Nabinger, Zachary Vega, +9

Scientific Reports

VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system

Jonathan So, Nathaniel W. Mabe, Bernhard Englinger, +19

JCI Insight

Dna MethylationCell DeathCollateral LethalityCancer BiologyGlioma +14

Systematic profiling of conditional degron tag technologies for target validation studies

Daniel P. Bondeson, Zachary Mullin-Bernstein, Sydney Oliver, +16

Nature Communications

Loss of miR-29a/b1 promotes inflammation and fibrosis in acute pancreatitis

Shatovisha Dey, Lata Udari, Primavera Riverahernandez, +6

JCI Insight

Sparse dictionary learning recovers pleiotropy from human cell fitness screens

Joshua Pan, Jason J. Kwon, Jessica A. Talamas, +7

Cell Systems

Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice

Kayla Quirin, Jason J. Kwon, Arafat Alioufi, +10

Molecular Therapy — Methods & Clinical Development

miR-29a Is Repressed by MYC in Pancreatic Cancer and Its Restoration Drives Tumor-Suppressive Effects via Downregulation of LOXL2

Shatovisha Dey, Jason J. Kwon, Sheng Liu, +5

Molecular Cancer Research