Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Susan Wyllie, Stephen Brand, Michael G. Thomas, +46

Proceedings of the National Academy of Sciences

Discovery of a Novel Class of Orally Active Trypanocidal <i>N</i>-Myristoyltransferase Inhibitors

Stephen Brand, Laura A. T. Cleghorn, Stuart P. McElroy, +17

Journal of Medicinal Chemistry

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Chidochangu P. Mpamhanga, Daniel Spinks, L.B. Tulloch, +9

Journal of Medicinal Chemistry

Chemical Validation of Trypanothione Synthetase

Leah S. Torrie, Susan Wyllie, Daniel Spinks, +7

Journal of Biological Chemistry

Dissecting the essentiality of the bifunctional trypanothione synthetase‐amidase in <i>Trypanosoma brucei</i> using chemical and genetic methods

Susan Wyllie, Sandra L. Oza, Stephen Patterson, +3

Molecular Microbiology

Genetic MethodsAntiparasitic AgentImmunologyMolecular BiologyCell Death +17

Cyclic nucleotide signalling: a molecular approach to drug discovery for Alzheimer's disease

Lydia Gibson, Ian McPhee, J. Kewney, +5

Biochemical Society Transactions

Molecular BiologyEpac Camp-binding SiteNeurochemical BiomarkersChemical BiologyMolecular Pharmacology +15

Investigation of Trypanothione Reductase as a Drug Target in <i>Trypanosoma brucei</i>

Daniel Spinks, Emma Shanks, Laura A. T. Cleghorn, +7

ChemMedChem

Drug TargetBioorganic ChemistryT. Brucei TryrAntiparasitic AgentMalaria +14

4-(Phenylsulfonyl)piperidines:  Novel, Selective, and Bioavailable 5-HT_2AReceptor Antagonists

Stephen R. Fletcher, Frank Burkamp, Peter Blurton, +16

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical SciencePharmacological StudyBiochemistry +12

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Michael G. Thomas, Manu De Rycker, Myriam Ajakane, +49

Journal of Medicinal Chemistry

Translational MedicineMedicinal ChemistryLeishmania DonovaniNew Candidate DrugsParasitic Protozoa +12

Design, Synthesis and Biological Evaluation of Novel Inhibitors of <i>Trypanosoma brucei</i> Pteridine Reductase 1

Daniel Spinks, Han B. Ong, Chidochangu P. Mpamhanga, +9

ChemMedChem