Alkylating DNA damage stimulates a regulated form of necrotic cell death

Wei‐Xing Zong, Dara Ditsworth, Daniel Bauer, +2

Genes & Development

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

Eveline S. Arnold, Shuo‐Chien Ling, Stephanie C. Huelga, +15

Proceedings of the National Academy of Sciences

Rna ProcessingNeurodegenerative DiseasesAmyotrophic Lateral SclerosisMedicineGenetics +13

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

Kathrin Meyer, Laura Ferraiuolo, Carlos J. Miranda, +12

Proceedings of the National Academy of Sciences

Activation of Poly(ADP)-ribose Polymerase (PARP-1) Induces Release of the Pro-inflammatory Mediator HMGB1 from the Nucleus

Dara Ditsworth, Wei‐Xing Zong, Craig B. Thompson

Journal of Biological Chemistry

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

Shuying Sun, Ying Sun, Shuo‐Chien Ling, +11

Proceedings of the National Academy of Sciences

HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

Jessica A. Bertout, Amar J. Majmundar, John D. Gordan, +6

Proceedings of the National Academy of Sciences

Hif2alpha InhibitionApoptosisCell DeathCancer BiologyTumor Biology +14

α4 Is an Essential Regulator of PP2A Phosphatase Activity

Mei Kong, Dara Ditsworth, Tullia Lindsten, +1

Molecular Cell

Signal TransductionSignaling PathwayBiochemistryMolecular PathwayNatural Sciences +5

Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1

Adrian Israelson, Dara Ditsworth, Shuying Sun, +15

Neuron

Signal TransductionCell TraffickingImmunologyCell MigrationMisfolded Sod1 +5

DNA Alkylating Therapy Induces Tumor Regression through an HMGB1-Mediated Activation of Innate Immunity

Jennifer L. Guerriero, Dara Ditsworth, Joseph M. Catanzaro, +5

The Journal of Immunology

Tumor XenograftsCancer ImmunosurveillanceHmgb1-mediated ActivationMedicineImmunology +13

Oligomerization Is a General Mechanism for the Activation of Apoptosis Initiator and Inflammatory Procaspases

David Chang, Dara Ditsworth, Hongtu Liu, +3

Journal of Biological Chemistry