Thomas A. Chappie

Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand

Lei Zhang, Anabella Villalobos, Elizabeth M. Beck et al. · Journal of Medicinal Chemistry · 2013 · 199 citations · Full text

Pet Ligands, Pet-mri, Novel Phosphodiesterase 2A +16

Phosphodiesterase 10A inhibitors: a novel approach to the treatment of the symptoms of schizophrenia.

Frank S. Menniti, Thomas A. Chappie, John M. Humphrey et al. · PubMed · 2007 · 114 citations

Neuropsychology, Psychopathology, Novel Approach +18

Discovery of a Series of 6,7-Dimethoxy-4-pyrrolidylquinazoline PDE10A Inhibitors

Thomas A. Chappie, John M. Humphrey, Martin P. Allen et al. · Journal of Medicinal Chemistry · 2006 · 112 citations · Full text

Combinatorial Chemistry, 6,7-Dimethoxy-4-pyrrolidylquinazoline Pde10a Inhibitors, Pharmacotherapy +16

Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition

Thomas A. Chappie, Christopher J. Helal, Xinjun Hou · Journal of Medicinal Chemistry · 2012 · 96 citations · Full text

Drug Target, Altmetric Attention Score, Pharmacotherapy +16

Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia

Christopher J. Helal, Zhijun Kang, Xinjun Hou et al. · Journal of Medicinal Chemistry · 2011 · 52 citations · Full text

Combinatorial Chemistry, Drug Target, Molecular Biology +21