Patrick H. Beusker

“Cascade‐Release Dendrimers” Liberate All End Groups upon a Single Triggering Event in the Dendritic Core

Franciscus M. H. de Groot, C. Albrecht, Ralph Koekkoek et al. · Angewandte Chemie International Edition · 2003 · 239 citations · Full text

Life Sciences, Biochemistry, Chemical Biology +12

Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985

Ronald C. Elgersma, Ruud G. E. Coumans, Tijl Huijbregts et al. · Molecular Pharmaceutics · 2015 · 219 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers

Miranda M.C. van der Lee, Patrick G. Groothuis, Ruud Ubink et al. · Molecular Cancer Therapeutics · 2015 · 215 citations

Pharmacy, Oncology, Pharmacology +16

Preclinical Profile of the HER2-Targeting ADC SYD983/SYD985: Introduction of a New Duocarmycin-Based Linker-Drug Platform

Wim H.A. Dokter, Ruud Ubink, Miranda van der Lee et al. · Molecular Cancer Therapeutics · 2014 · 163 citations · Full text

Pharmacy, Oncology, Pharmacology +17

SYD985, a Novel Duocarmycin-Based HER2-Targeting Antibody–Drug Conjugate, Shows Antitumor Activity in Uterine Serous Carcinoma with HER2/Neu Expression

Jonathan Black, Gulden Menderes, Stefania Bellone et al. · Molecular Cancer Therapeutics · 2016 · 92 citations · Full text

Medicine, Oncology, Pharmacology +17