Robert M. Friedlander

Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

Chiara Zuccato, Andrea Ciammola, Dorotea Rigamonti et al. · Science · 2001 · 1.3K citations

Neurodegenerative Diseases, Wild-type Huntingtin Activity, Bdnf Production +12

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

Shan Zhu, Irina G. Stavrovskaya, Martin Drozda et al. · Nature · 2002 · 1.1K citations

Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Medicine +7

Neurotoxicity induces cleavage of p35 to p25 by calpain

Ming‐Sum Lee, Young T. Kwon, Mingwei Li et al. · Nature · 2000 · 1.1K citations

Biochemistry, Medicine, Neuropharmacology +4

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

Minghua Chen, Victor Ona, Mingwei Li et al. · Nature Medicine · 2000 · 1K citations

Delays Mortality, Cell Death, Degenerative Disease +8

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

Hideaki Hara, Robert M. Friedlander, Valeria Gagliardini et al. · Proceedings of the National Academy of Sciences · 1997 · 833 citations · Full text

Immunology, Cpp32-like Caspases, Cell Death +25